The coronavirus disease outbreak has proven to be a major health crisis affecting virtually every facets of our lives. Coronavirus disease is an ongoing pandemic disease. The disease which is caused by a new type of virus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many patients hospitalized with COVID-19 will develop muscle weakness particularly those admitted in intensive care unit (ICU). Studies have shown that muscle weakness is one of the direct consequences of critical illness. We systematically reviewed literature that quantified changes in muscle strength and it relationship with COVID- 19 in Intensive care unit in humans.

Keywords: COVID-19, Respiratory, ICU, Muscle weakness, Pandemic.

Richard T.D Appleton, John Kinsella, Tara Quasim. (2015).The incidence of intensive care unit-acquired weakness syndromes: A systematic review. J Intensive Care Soc. 16(2): 126.

Stevens R.D, Dowdy DW,Michaels RK, Mendez-Tellez PA, Pronovost PJ Needham DM. (2007). Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med, vol. 33 (pg. 1876-91).

Fan E, Cheek F, Chlan L et al (2014). An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J RespirCrit Care Med 190:1437–1446.

Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, Lee M.( 2020). Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State JAMA.323(16):1612-1614.

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Yang X, Yu Y, Xu J, at al. Lancet. 2020; 8(5):475-481.

Showalter CJ, Engel AG. (1997).Acute quadriplegic myopathy: analysis of myosin isoforms and evidence for calpain-mediated proteolysis. Muscle Nerve. 20(3):316-22.

De Jonghe B, Sharshar T, Lefaucheur JP, et al. (2002). Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA.;288(22):2859-2867.

Wells C, Steinbrenner G, Beans J, et al. Severe immobility and malnutrition in post ICU patients requiring prolonged mechanical ventilation: an unmet rehabilitation need. Am J RespirCrit Care Med. 2012;185:A6852.

Herridge MS, Tansey CM, Matt A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011;364 (14):1293-1304.

Koch S, Spuler S, Deja M, et al. Critical illness myopathy is frequent: accompanying neuropathy protracts ICU discharge. J Neurol Neurosurg Psychiatry. 2011;82:287-293.

J. Horn, G Hermans. (2017). Intensive Care Unit-Acquired Weakness. HandbClin Neurol.141:531-543.

Leigh Ann Callahan, Gerald S. Supinski.(2013). Prevention and Treatment of ICU Acquired Weakness – Is There a Stimulating Answer?. Crit Care Med. 41(10): 2457–2458.

Christie M Lee, Eddy Fan. (2012). ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients? BMC Med 10, 115.

Richard D. Zorowitz, MD. (2016).ICU–Acquired Weakness A Rehabilitation Perspective of Diagnosis, Treatment, and Functional Management.chest; 966-71.

Simone Piva,  Nazzareno Fagon, Nicola Latronico. Intensive care unit–acquired weakness: unanswered questions and targets for future research [version 1; peer review: 3 approved]. F1000Research 2019, 8(F1000 Faculty Rev):508.

Richard Appleton,  John Kinsella. (2012). Intensive care unit-acquired weakness. Continuing Education in Anaesthesia Critical Care & Pain. 12(2);  62–66.

Hermans G, and Van den Berghe G. (2015).Clinical review: intensive care unit acquired weakness. Crit Care. 2015; 19(1): 274.

Babatunde Oyeneyin, Opeyemi Adeloye, Oyeneyin Oluwatosin, Odewumi O. (2020).An Overview of COVID-19 in Nigeria from the Index Case till Now. IJARIIE (1):789.

Zhou, C., Wu, L., Ni, F., Ji, W., Wu, J., & Zhang, H. (2014). Critical illness polyneuropathy and myopathy: a systematic review. Neural regeneration research, 9(1), 101–110.

Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020 February 24 (Epub ahead of print).

Abdelnour, L., Eltahir Abdalla, M., & Babiker, S. (2020). COVID 19 infection presenting as motor peripheral neuropathy. Journal of the Formosan Medical Association = Taiwan yi zhi, 119(6), 1119–1120.