Mesenchymal stem cells are multipotent stromal stem cells that can differentiate to any kind of cells like bone, cartilage, adipose, muscles, and neural cells. Mesenchymal stem cells can be derived from different tissues such as bone marrow, dental pulp, adipose tissues, and umbilical cord. But the human umbilical cord is the rich source of mesenchymal stem cells that are usually collected at the birth of a child, are being used in the treatment of auto-immune disease and also for treating diseases of the blood. In the past, most of the diseases were used to treat by the transplantation of organs or by embryonic stem cells. But transplantation of organs usually carries the risk of organ rejection and the other major drawback of this treatment is the unavailability of the proper donor. And if we use pre-specialized will produce only specific cells. While in umbilical cord therapy, we use stem cells that are not pre-specialized. The hUCMSCs are being used in the cochlea to repair sensorineural hearing, they are being used for the treatment of the corneal diseases, liver cirrhosis, liver fibrosis, diabetes mellitus, dilated cardiopathy, neurodegenerative diseases, joint pathologies, radiation-induced lung injury, and periventricular leukomalacia. The umbilical cord mesenchymal stem cells can be obtained from umbilical cord blood that contains hematopoietic stem cells, and also from Wharton’s jelly, cord lining, perivascular region. The purpose of this study is to evaluate the use of hUCMSCs for treatment of a different type of blood, immune system, neurodegenerative disease, and to check the effect of pigment epithelium-derived factor on hUCMSCs and effect of hexachlorophene on hUCMSCs.
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