Middle East Journal of Applied Science & Technology

Volume 3 Issue 3 July-September 2020

Research Article

Curcumet capsules: A Natural Antioxidant, Anti-Inflammatory Offers Similar Efficacy as NSAIDS without any Side Effect

Govind Shukla, Monica Yadav, Uddhav L Kanade, Ramya Charitha Swamireddy, Arun Kumar Junjipelly & C.J.Sampath Kumar

Page No. 01-08

 Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, and indomethacin, are commonly prescribed to reduce pain and inflammation, yet their popularity is waning as many serious side effects have emerged. Ironically, long-term use of these drugs can worsen joint health by accelerating the breakdown of cartilage. NSAIDs can cause serious and life-threatening side effects such as stomach ulcers and bleeding, increased gut permeability, water retention, and kidney damage, risk of heart attacks. Curcumin Extract in curcumet capsules has antioxidant, anti-inflammatory, actions. Curcumin exerts anti-inflammatory activity by inhibition of a number of different molecules that play an important role in inflammation. Turmeric is effective in reducing post-surgical inflammation. Turmeric helps to prevent atherosclerosis by reducing the formation of bloods clumps. Curcumin inhibits the growth of Helicobacter pylori, which causes gastric ulcers and has been linked with gastric cancers. Curcumin can bind with heavy metals such as cadmium and lead, thereby reducing the toxicity of these heavy metals. This property of curcumin explains its protective action to the brain. Curcumin acts as an inhibitor for cyclooxygenase, 5-lipoxygenase and glutathione S-transferase. Osteoarthritis is a degenerative joint disease that is the most common type of arthritis. Causes OA is caused by joint damage. This damage can accumulate over time, which is why age is one of the main causes of the joint damage leading to osteoarthritis. Osteoarthritis occurs when the cartilage that cushions the ends of bones in your joints gradually deteriorates. Cartilage is a firm, slippery tissue that enables nearly frictionless joint motion. It causes changes in the bone and deterioration of the connective tissues that hold the joint together and attach muscle to bone. The aim of the study was to determine efficacy and safety of the efficacy and safety of curcumin with those of diclofenac in the treatment of knee osteoarthritis (OA), who is intolerant to the side effects of non-steroidal anti-inflammatory drugs. A total of 80 patients were enrolled as per inclusion and exclusion criteria, patients were participated in this study, and the response was 100%. The diagnosis of Osteoarthritis in the study subjects was based on the following clinical symptoms history of Nausea, vomiting, Diarrhea, Abdominal pain, Constipation, Dyspepsia, Weakness at the first day of pharmacokinetic assessment. Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Based on these facts A Natural immunomodulatory agent CURCUMET CAPSULES has been Developed by R&D Centre, Lactonova Nutripharm (P) Ltd., Hyderabad. The present paper Reviews the Role of CURCUMET CAPSULES, A Better alternative treatment option in the patients with knee OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.

Research Article

Innovative Small Size Plant for the Production of Biogas and Electric Energy from Biomass

Farné Stefano

Page No. 09-27

 Abstract: The interest for Renewable Energy Sources (RES) has strongly increased due to the need to reduce the greenhouse gas (GHG) emissions, as indicated, in particular, by the renewable energy directive 2018/2001/EU and to reuse organic waste and by-products that would otherwise have to be disposed of in an expensive way. The present article relates to a method and to a device to decompose a biomass matrix and to selectively extract methane, carbon dioxide, NPK (nitrogen, phosphorus and potassium) salts and clarified water. This method and device is the subject of an Italian and European patent registered by Stefano Farné and Vito Lavanga under the name of MBGC (Mini BioGas Continuous). The MBGC can be applied to the production of biomethane (for thermal and electrical purposes), of organic (protein and oleic) substances, of NPK salts, that can be used in the production of biofuels, fertilizing mixtures for various industrial sectors (livestock farms, chemical, etc.), of hydrogen, as present in solution in the liquid phase and of carbon dioxide for agronomic industries, metallurgical industries, fire services, agro-food etc. It has been analysed a meaningful literature on the subject of biogas production plants, with specific focus to those of small size and subsequently the MBGC plant is described in detail from the point of view of both plant engineering and its operation.

Review Article

Applications of Artificial Intelligence in Human Life

Mohd Meraj Ahemad, Iqbal Ahmad, Dr. Javed Ashraf, Dr. Safdar Tanweer & Dr. Anisur Rehman Nasir

Page No. 28-38

 Abstract: Artificial Intelligence (AI) has revolutionized in information technology.AI is a subfield of computer science that includes the creation of intelligent machines and software that work and react like human beings. AI and its Applications gets used in various fields of life of humans as expert system solve the complex problems in various areas as science, engineering, business, medicine, video games and Advertising. But “Do any traffic lights use Artificial Intelligence??”, I thought a lot of this when waiting in a red light. This paper gives an overview of Artificial Intelligence and its applications used in human life. This will explore the current use of Artificial Intelligence technologies in Network Intrusion for protecting computer and communication networks from intruders, in the medical area-medicine, to improve hospital inpatient care, for medical image classification, in the accounting databases to mitigate the problems of it, in the computer games, and in Advertising. Also, it will show artificial intelligence principle and how they were applying in traffic signal control, how they solve some traffic problem in actual. This paper gives an introduction to a self-learning system based on RBF neural network and how the system can simulate the traffic police’s experience. This paper is focusing on how to evaluate the effect of the control with the changing of the traffic and adjust the signal with the different techniques of Artificial Intelligence.

Research Article

Hayvit Trio Chewable Tablets: A Clinical Study on Effective Supplementation for Cellular Function of both Innate and Adoptive Immunity

Dr. Somendra Shukla, Dr. M. Sampoorna, Dr. Pranitha Ramswaroop, Sangeeta Kumari R & D. Madugula Mahender

Page No. 39-50

 Abstract: Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C and other Natural Ingredients helps these white blood cells function more effectively while protecting them from damage by potentially harmful molecules, such as free radicals. Vitamin D assists in skin repair and helps fight off infection as well as decrease inflammation. Zinc is crucial for normal development and function of cells mediating innate immunity, neutrophils, and NK cells. Macrophages also are affected by zinc deficiency. Phagocytosis, intracellular killing, and cytokine production all are affected by zinc deficiency. Vitamin B6 is vital to supporting biochemical reactions in the immune system. Vitamin B9 (that is, folate or folic acid) is essential for nucleic acid and protein synthesis, and inadequate levels of vitamin B9 dramatically alter the immune response. Hayvit Trio fights against the Viral infection and boosts the immunity in prophylaxis. Colostrum is for boos immunity due to its high concentration of the antibodies IgA and IgG. Hayvit trio ™ Orange flavor chewable tablets which improves the immunity either adaptive or innate immunity.

Technical Report

Report on Multiple Antibiotics Resistance Aeromonas hydrophila Isolated from Catfish Farms in Epe Lagos

Ogbonne, Fabian Chinedu, Akhiromen Dorathy Iniobong & Wilfred-Ekprikpo, Peace Chidinma

Page No. 51-57

 Abstract: Many Gram negative bacteria, especially Aeromonas hydrophila are notorious for their heightened capacity to acquire and exchange antibiotic resistance genes and consequently, are commonly targeted as indicator organism for monitoring antimicrobial resistance in aquatic milieus. This study was aimed to investigate the prevalence and drug resistance patterns of Aeromonas hydrophila isolated from farm raised catfish at Epe fish farm, Lagos State, Nigeria. Swabs were aseptically taken from the kidney, intestine, liver, gills, and skin after dissecting the fish samples. The specimens were bacteriologically analyzed. After series of biochemical test, the isolated bacteria were identified presumptively according to Bergey’s Manual of determinative bacteriology, 7th Edition. Fifty-seven (57) Aeromonas hydrophila were recovered out of seventy-one (71) bacterial isolated from the 35 fish samples collected from the fish farms studied. The study reveals multiple antibiotics resistance pattern among the isolates as Aeromonas hydrophila were 100% resistant to Streptomycin, Oxytetracycline, Chloranphenicol, Pefloxacin, Ofloxacin and 70, 65 and 55% resistant to Gentamycin, Amoxycillin and Erythromycin respectively. However, all the isolates were 100% susceptible to Ciprofloxacin and Cotrimoxazole only. The presence of multidrug-resistant Aeromonas hydrophila in fish could be a vehicle of horizontal gene transfer to previously susceptible bacteria and these could constitute a serious public health hazard to human and animal in the environment. Thus, the use of antibiotics in catfish production as growth promoter or disease prevention should be discouraged and some safer, biological alternatives strategies should suffice to mitigate bacteria drug resistance and its associated problems.

Review Article

Factors Affecting Employee’s Satisfaction about Workplace Environment: A Micro-Survey Study

Md. Abdul Goni, K. M. Mustafizur Rahman & Md. Mostafizur Rahman

Page No. 58-67

 Abstract: In poor setting workplace environment in Bangladesh, most of the employees are bound to work due to the scarcity of job. Despite remarkable progresses in industrial sectors over the last few decades employees are facing two types of disadvantages; one they are working with dissatisfied workplace environment and lower wages on the other. It is the reality of the most of the employees in industrial sectors especially in the physical labour oriented industries. This study based on the information collected from 417 employees of three physical labour based aluminum industries in Rajshahi city of Bangladesh. Results of this study highlight that there are a strong variation in the satisfaction level of the employees about the workplace environment by their socio-demographic characteristics. It is believed that the findings of the study will facilitate policy-makers and respected authorities to take timely and viable steps and develop workable strategies to address the issue of sound workplace environment in the industrial sector. Without ensuring employees satisfaction through better workplace environment, it is difficult to reach sustainable development of the country.

Review Article

Educational Gaming Mobile App in Assisting Kids in Learning Math and English

Prince Kelvin Owusu & Raul Asante Adjei-Boateng

Page No. 68-80

 Abstract: Education in every country is very critical to each one of us. This project seeks to identify the problems associated with learning at the elementary level, and the highlights the effects of poor educational foundations have on children when they grow to learn at the advanced level. The project proposes the designing and implementing of an educational video game app that can assist children from ages 2 to 7 years in overcoming the challenges associated with poor educational foundation in most developing countries in Africa especially. This app is design by creating an intuitive mobile application that will aid in the understanding of basic concepts associated with learning and the ability for elementary school children to employ this in their respective everyday activities. The project is also designed to encourage children in the whole study process hence not making it boring but exciting and more fun for children as well. It also seeks to help parents’ teachers and guardians to track the progress of children who use the application and helps them know the needed support that they require to make each study session a success. The study incorporates a rigorous literature review that seeks to identify all the gaps associated with solving the problem. This project adopts the Scrum methodology. The scrum method is a simple adaptive framework to deliver working software in sprints. It has three main stakeholders the Product owner, scrum master and the team members. It uses two main artifacts namely the product backlog and the sprint backlog to guide the team during sprints. The study concluded that the use of educational video games in learning math and English by the children is helpful since the children can quickly grasp the concepts within very short period.

Research Article

Acute Abuse of Tramadol Induces Intensive Pulmonary Histopathological Trauma in Rats - An Experimental Comprehensive Overview

G. El-Sherif & H. K. Abdel-Zaher

Page No. 81-119

 Abstract: Tramadol is a narcotic-like pain reliever used in medicine to treat moderate to severe pain in adults after an operation or a serious injury. It is also used to treat long-standing pain when weaker painkillers no longer work. Tramadol works by blocking pain signals from travelling along the nerves to the brain. It can still be addictive if abused, especially when taken for a long period of time (chronic) or when taken in larger doses (acute) as a narcotic rather than a pain-killer. In this comprehensive histopathological study, the commercial tramadol hydrochloride prescribed in Egypt was used in both forms, as a solution of 100 mg ampoules or as 225 mg tablets. Male adult Wistar rats (Rattus norvegicus) were used as experimental models that were administered tramadol orally and injection for regular durations and calculated dose concentrations. Some reliable histological, histochemical, immunocytochemical and ultrastructural techniques were applied to investigate the experimental manifestations and life-threatening signs/symptoms of tramadol poisoning and to check the traumatic histopathological and biochemical impacts of tramadol abuse in acute administration modality on lungs of rats. Many histopathological lesions e.g., toxicity Lymphocyte infiltration, hemorrhage, necrotic areas, cytoplasmic and membranous degenerations, depletion or increase of some biomolecules, ultrastructure damages and immunocytochemical signs were recorded. These results were described, evaluated and confirmed to a variety of recent studies. It was concluded that, use of tramadol as a pain-killer in medicine or as an abused narcotic among addicts, should be controlled and we are in need for more extensive attention to the clinical and narcotic abuse of tramadol.