Mitochondrian of the cells play a vital role in the production of energy at cellular level which is essential for the survival of a cell. CoQ10 is one of the coenzyme in the electron transport chain in the inner mitochondrial membrane where oxidative phosphorylation occurs for the production of ATP from the reducing equivalents such as NADPH2, FADH2, etc. Besides, CoQ10 works as an antioxidant, protecting lipids and other cell components from oxidation. Thus, it is a particularly promising cardioprotective agent. Apart from this there are so many functions of CoQ10 which are vital for the sustenance of life. When cells age, mitochondrial CoQ10 levels decrease. But dietary supplementation has been shown to help, maintain energy production and aid persons against disorders of CoQ10 deficiency disorders. This review gives an overview of functions of the CoQ10, reports related to consumption versus alleviation of diseases and its importance of dietary supplement in now a days life.
Keywords: CoQ10, Energy Production, Nutrient.
Crane FL. et al., Isolation of a quinine from beaf heart mitochondria. Biochimica et Biophys Acta.1957; 25:220-221.
Littaru GP. Energy and Defence. Rome. 1955:14-24.
Littaru GP. Ho L and Folkers K.Deficiency of CoQ10 in human heart disease. Part I and II. Int J Vit Nutr Res. 1972; 42(2):291.
Mitchell P. Possible molecular mechanisms of the proton motive function of cytochrome systems. J. Theoret Biol. 1976; 62:327 – 367.
Langsjoen PH, Vadhanavikit S andFolkers K. Response of patients inclasses III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc natl Acad of Sci. 1985; 82: 4240 – 4244.
Ernster L and Forsmark P. Ubiquinol:an endogeneous antioxidant in aerobic organisms. Seventh International Symposium on Biomedical and Clinical Aspects of Coenzyme Q.
Folkers K. et al. (eds.) The Clin Inves.1993; 71(8): 60 – 65.
Kidd PM. et al. Cozenzyme Q10: Essential Energy Carrier and Antioxidant. HK Biomedical consultants. 1988; 1-8.
Mc Guinre JJ. et al.. Succinate ubiquinone reductcase linked recycling of alphatocopherol in reconstituted systems and mitochondria: requirement for reduced ubiquinol. Arch Bio chem Biophys. 1992; 292; 47-53.
Kalen A, Appelkvist EL, Dallner G.Age-related changes in the lipid compositions of rat and human tissues. 1989 : 24: 579-581.
Ghirlanda G. et al. Evidence of plasmaCoQ10 –lowering effect by HMGCOA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharm. 1993; 33(3): 226-9.
Lasjoen PH. et al. Long –term efficacy and safety of Coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J cardiol.1990; 65: 512-23.
Langsjoen PH, Langsjoen P andFolkers K. Isolated diagnostic dysfunction of the myocardium and its response to CoQ10 treatment. Clin Invest. 1993; 71(8): S140-4.
Proceedings from American College of Cardiology: Women and Heart Disease. March 15, 1997.
Oda T. Coenzyme Q10 therapy on the cardiac dysfunction in patients with mitral valve prolapse. Dose vs. effect and dose vs. serum level of Coenzyme Q10. In: Folkers, K, YamamuraY, (eds.). Biomedical and Clinical Aspects of Coenzyme Q10, vol5, Elsevier Sci Publ B.V., Amsterdam, 1986; 17: 873-878.
Otani T, Tnaka H, Onoue T. et al. In Vitro study on contribution of oxidative metabolism of isolated rabbit heart mitochondria to myocardial reperfusion injury Circ Rs.1984; 55:168-175.
Fujioka T, Sakamoto Y and Mimura G. Clinical study of cardiac arrhythmias using a 24 hour continuous electro cardiographic recorder (5threport)- Antiarrhythmic action of Coenzyme Q10 in diabetes. Tohoku J Exp Med. 1983; 141: 453-463.
Chen YF, Y T, WU SC. Effectiveness of Coenzyme Q10 on myocardial preservation during hypotherimic cardio plegic arrest. J thrac Cardiovas Surg. 1994; 107: 242-7.
Sunamori M, Tanaka H, Marvyama T.et al. Clinical experience of CoQ10 to enhance interoperate myocardial protection in coronary artery revascularization. Cardivasc Drug Therapy. 1991; 5: 297-300.
NAlar WG. The use of Coenzyme Q10ischaemia heart muscle. In: of Cenzyme Q vol 2; Esevier, North Holland, Biomedical press, Amsterdam.1980;409-425.
Frei B, Kim MC and Ames BN.Ubiquinol-10 is an effective lipid soluble antioxidant at physiological concentrations. Proc Natl Acad Sci.1990; 87: 48-79-48883.
Thomas SR, Neuzil J and Stocker R.Inhibition of LDL oxidation byUbiquinol-10. A protective Mechanism for Coenzyme Q in athero genesis? In: Littarru GP, AllevaR, Battino M, Folkers K. (eds) Mol Aspects of Med. 1997; 18: 1 –309.
Suzuki H. et al. Cardiac performance and Coenzyme Q10 in thyroid disorders. Endocrinol Japan. 1984; 31:755.
Kishi Y. et al. Protective effect of Coenzyme Q on Andriamycin toxicityin beating heart cells, IN: Biomedical and Clinical Aspects of Coenzyme Q vol 4, Folkers K, Yamamura Y. (eds.) Elsevier. 1984:181-188.
Ogura R. et al. The role of ubiquinone (Coenzyme Q10) in preventing Adriamycin-induced mitochonodrial disorders in rat heart. J Appl Biochem,1979; 1: 325-335.
Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1956:11:298-300.
Beyer RE, Emster. The antioxidant roleof Coenzyme Q. In: Lenaz, G. et al. (eds): Highlights in Ubiquinone Research. Taylor and Francis, London.1990:191-213.
Villaba JM. et al. Role of cytochromeb5 reductase on the antioxidant function of Coenzyme Q in the plasma membrane. Molec Apects Med. 1997; 8:7-13.
Folkers K, Langsjeoen P, Nra T. et al. Biochemical deficiencies of CoenzymeQ10 in HIV- infection and exploratory treatment. Biochem Biophys Res Commun. 1988; 153: 888-896.
Folkers K. et al. Unpublished manuscript.
Hanioka T. et al. Therapy with Coenzyme Q10 for patients with perital disease. Effect of Coenzyme Q10 on the immune system, J of Dental Health. 1993; 43: 667-672.
Sano M. et al. A Controlled trial of selegiline, alpha-to copherol or both as treatment for Alzheimer’s disease. Eng J of Med. 1997; 336: 1216-22.
Edulnd C, Soderberg M and Kristenssion K. Isoprenoids in aging and neuro degeneration. Neurochemisrty Int. 1994; 25: 35-38.
Fallon J. et al. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Exp Neurol. 1997; 144(1): 193-8.
Linnane AW. et al. Mitochondrial DNA mutation and the aging process: bioenergy and pharmacological intervention. Mutation Research.1992; 275: 195-208.
Jameson S. Statistical data support prediction of death within six months on low levels of Coenzyme Q10 and other entities. Clin Investg.1993; 71: 137-139.
Fujimoto S. et al. Effects of Coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung disease. Clin Investig. 1993; 71; 162-6.
Karisson J, Diamant B and Folkers K. Exercise –limiting factors in respiratory distress. Respiration.1992; 59(2): 18-23.
Poda M and Packer L. Ubiquinol a marker of oxidative stress in skin. Proceedings at the 9th International Symposium on Biomedical and Clinical Aspects of CoQ10. Ancona Italy, 1996.
Hoppe U. Coenzyme Q10-aCutaneous Antioxidant and Energizer. Presented at the First Conference of the International Coenzyme Q10 Association, 1998.
Jones R and Mann T. Damage to ramspermatozoa by peroxidation of endogenous phospholipids. Journal of Reproduction and Fertility.1977;50:261-268.
Karlson. et al. ubiquione, Alphatocopherol and cholesterol in man. International J Vit Nutr Research.1992; 62(2): 160-4.
Fiorella PL. et al. Metabolic effects of Cenzyme Q10 treatment in high level athletes. In: Biomedical and Cinical Aspects of Coenzyme Q, 1991, Vol.6.Folkers K, Ymagami T, Littaru GP. (eds) Elsevier. 613-520.
Folkers K and Simonsen R. Two successful double-blind trials with Coenzyme Q10 (vitamin Q10) and muscular dystrophies and neuro genicatrophies. Biochem Biophys Acta.1995; 1271(1): 281-6.
Barbiroli B. et al. Coenzyme Q10 improves mitochondrial respiration inpatients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorus magnetic resonance spectroscopy. Cell Mol bio. 1997; 43(5): 741-9.
A New Issue was published – Volume 8, Issue 4, 2025
10-10-2025 11-07-2025