Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, and indomethacin, are commonly prescribed to reduce pain and inflammation, yet their popularity is waning as many serious side effects have emerged. Ironically, long-term use of these drugs can worsen joint health by accelerating the breakdown of cartilage. NSAIDs can cause serious and life-threatening side effects such as stomach ulcers and bleeding, increased gut permeability, water retention, and kidney damage, risk of heart attacks. Curcumin Extract in curcumet capsules has antioxidant, anti-inflammatory, actions. Curcumin exerts anti-inflammatory activity by inhibition of a number of different molecules that play an important role in inflammation. Turmeric is effective in reducing post-surgical inflammation. Turmeric helps to prevent atherosclerosis by reducing the formation of bloods clumps. Curcumin inhibits the growth of Helicobacter pylori, which causes gastric ulcers and has been linked with gastric cancers. Curcumin can bind with heavy metals such as cadmium and lead, thereby reducing the toxicity of these heavy metals. This property of curcumin explains its protective action to the brain. Curcumin acts as an inhibitor for cyclooxygenase, 5-lipoxygenase and glutathione S-transferase. Osteoarthritis is a degenerative joint disease that is the most common type of arthritis. Causes OA is caused by joint damage. This damage can accumulate over time, which is why age is one of the main causes of the joint damage leading to osteoarthritis. Osteoarthritis occurs when the cartilage that cushions the ends of bones in your joints gradually deteriorates. Cartilage is a firm, slippery tissue that enables nearly frictionless joint motion. It causes changes in the bone and deterioration of the connective tissues that hold the joint together and attach muscle to bone. The aim of the study was to determine efficacy and safety of the efficacy and safety of curcumin with those of diclofenac in the treatment of knee osteoarthritis (OA), who is intolerant to the side effects of non-steroidal anti-inflammatory drugs. A total of 80 patients were enrolled as per inclusion and exclusion criteria, patients were participated in this study, and the response was 100%. The diagnosis of Osteoarthritis in the study subjects was based on the following clinical symptoms history of Nausea, vomiting, Diarrhea, Abdominal pain, Constipation, Dyspepsia, Weakness at the first day of pharmacokinetic assessment. Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Based on these facts A Natural immunomodulatory agent CURCUMET CAPSULES has been Developed by R&D Centre, Lactonova Nutripharm (P) Ltd., Hyderabad. The present paper Reviews the Role of CURCUMET CAPSULES, A Better alternative treatment option in the patients with knee OA who are intolerant to the side effects of non-steroidal anti-inflammatory drugs.

Keywords: Curcumet capsules, Curcumin, Osteoarthritis, Diclofenac.

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