The implementation of efficient preventative measures is dependent on understanding of the molecular and cellular mechanisms of virus infections, emphasizing the importance of studying virus–host interactions at the cellular scale to hit targets for antiviral intervention and also to clarify critical viral genomes determinants which are critical for the development of severe disease. The synthesis and quantitative determination of an unique complex Co(III) comprising 1,10-phenanthroline (Phen) as a ligand are described in this paper. The absorption properties of COVID-19 virus in neat solvent in the existence of 4.5 percent BSA, as well as the biological communication of COVID-19 virus via molecular docking, have already been summarized. The complexes' absorbance spectra show distinct intense peaks that correspond to intra ligand and charge transfer shifts. In moreover, the complex in 4.5 percent BSA exhibits a blue shift in absorption studies, which correlates to LCT and MLCT transformations endorsed by van der Waals with BSA protein. Absorption studies showed the quenching of spectral values caused by BSA interaction with complexes. The molecular docking analysis of the complex mostly with COVID-19 virus (PDB: 6LU7) indicated a positive polar contact between different amino acids throughout the spike protein. The complex exhibits excellent binding energies in the range of -7.6 kcal/ mol. As a result, they have the capability to be spur molecules for advancement of candidates against SARS-COV-2. The absorption spectral behavior of our complex in solvent and 4.5 percent BSA has been discovered to demonstrate the importance of our complex in biological applications, particularly in COVID-19 treatment studies. We also reviewed the complex's basic strengths, including such potential and steric energy, using Gaussian hypothalamus responds.

Keywords: Covid-19, Molecular docking, LCT and MLCT, Serum albumin, Cobalt complex, Phenanthroline drug.

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