The Target of today’s healthcare system is delivering medicine directly from the manufacturer to end-user. The pharmaceutical supply chain involves distributors, manufacturers, wholesalers, and customers. The biggest challenge related to this supply chain is temperature monitoring also as counterfeit drug prevention. Many drugs and vaccines remain viable within a selected range of temperatures. If exposed beyond this temperature range, the drugs do not work as intended. Many of the world’s top-selling medicines are sensitive and need cold-chain shipping, i.e., storing goods during a temperature-controlled environment. Keeping the drugs cold is an important a part of the availability chain that connects drug producers to patients. But storing the essential information associated with cold-chain shipping in centralized databases is often susceptible to manipulations or data hacks. Also, the present software doesn't have tracking capability of maintaining a full chain of identity. One of the most reliable solutions would be the integration of IoT sensors with blockchain. To store the essential information related to cold-chain shipping in a blockchain network so, it becomes impossible for the data to get manipulate by anyone unlike centralized databases.

Keywords: Pharmaceutical supply chain, Cold-chain shipping, Blockchain, Temperature-controlled environment.

[1] Ben Fekih, R., Lahami, M. (2020). Application of Blockchain Technology in Healthcare: A Comprehensive Study. In: Jmaiel, M., Mokhtari, M., Abdulrazak, B., Aloulou, H., Kallel, S. (eds) The Impact of Digital Technologies on Public Health in Developed and Developing Countries. ICOST 2020. Lecture Notes in Computer Science, Vol 12157. Springer, Cham. https://doi.org/10.1007/978-3-030-51517-1_23.

[2] Uslu, B.Ç., Okay, E. & Dursun, E. (2020). Analysis of factors affecting IoT-based smart hospital design. J Cloud Comp., 9: 67. https://doi.org/10.1186/s13677-020-00215-5.

[3] Angelov, G.V., Nikolakov, D.P., Ruskova, I.N., Gieva, E.E., Spasova, M.L. (2019). Healthcare Sensing and Monitoring. In: Ganchev, I., Garcia, N., Dobre, C., Mavromoustakis, C., Goleva, R. (eds) Enhanced Living Environments. Lecture Notes in Computer Science(), vol 11369. Springer, Cham.

[4] Musamih, A., Jayaraman, R., Salah, K., Hasan, H. R., Yaqoob, I., & Al-Hammadi, Y. (2021). Blockchain-Based Solution for Distribution and Delivery of COVID-19 Vaccines. IEEE access: practical innovations, open solutions, 9: 71372-71387. https://doi.org/10.1109/ACCESS.2021.3079197.

[5] Tagde, P., Tagde, S., Bhattacharya, T. et al. (2021). Blockchain and artificial intelligence technology in e-Health. Environ Sci Pollut Res., 28: 52810-52831. https://doi.org/10.1007/s11356-021-16223-0.