Rodents, as mice and rats are the most common laboratory animals used in research and testing. The parasite infections can affect investigations by inducing physiological and immunological alterations in the hosts, increasing or diminishing host susceptibility to experimental stress, inducing tissue damages stimulating abnormal tissue growth competing with the host for nutrients, decreasing the volume of host’s blood and body fluids and by mechanical interference. Therefore, the study aimed to determine the effects of different de-worming drugs on intestinal parasites in laboratory mice (Mus musculus) from August 2023 to January 2024. Before experiment, mice groups were checked and detected parasite’s eggs by the taping method. Intestinal parasites index 4 plus positive 30 males and 30 female mice and 10 each male and female were selected from colony and housed in cages in breeding rooms separately. Before treatment of de-worming drugs, 10 each of male and female mice will be housed in 8 cages separately according to de-worming drugs except control cages in the testing room at 22±2°C, RH 65±5% and good air ventilation. All the tested mice were given to free access the diet and tap water during the experimental period. Treatment regimens as Mebendazole, Albendazole and Praferan for mice were used orally administration of 10mg/kg/day for 10 consecutive days. After the de-worming test all the tested mice were checked and examined the intestinal parasites weekly till to fine reinfection. Results revealed that highest number of mice were Pinworm positive followed by Ascariasis. After intervention by three de-worming drugs on 4plus parasites positive mice were cleaned all kinds of intestinal parasites till 15 weeks expect Mebendazole. Albendazole and Praferan were found most effective de worming drugs for mice population. After 14weeks or during 15 weeks, Mebendazole treated mice were found 10% of reinfected by pin worm infection. Albendazole and Praferan are suitable de-worming drugs for laboratory mice. Intestinal parasite or worms are transmitted through fecal-oral contact (injection of embryonated eggs). Therefore, cages and its utensils of de-wormed mice should be cleaned with detergent daily and need to treat three monthly monitoring of parasite control plan in mice husbandry colony.

Keywords: Deworming Drugs, Laboratory Mice, Mus musculus, Effectiveness, Albendazole, Mebendazole, Praferan, Parasites, Taping Method, Positivity, Treatment, Clean.

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Source of Funding:

This study was financially supported by the DMR grant from Department of Medical Research.

Competing Interests Statement:

The authors declare no competing financial, professional, or personal interests.

Consent for publication:

The authors declare that they consented to the publication of this study.

Authors' contributions:

All the authors took part in literature review, analysis, and manuscript writing equally.

Ethical Approval:

Based on institutional guidelines.

Informed Consent:

Not applicable.