Keywords: Mass Spectrophotometry, Proteomics, Metabolomics, Clinical Laboratory, Drugs, Gas Chromatography, Immunoassays, Liquid Chromatography, Mass Spectrometry, Tandem Mass Spectrometry, Therapeutic Drug Monitoring, Toxicology.

[1] Heaney, L.M. (2020). Advancements in mass spectrophotometry as a tool for clinical analysis: Part I. Clin Chem Lab Med., 58(5): 639–42. doi: 10.1515/cclm-2020-0199.

[2] Savolainen, K., Kiimamaa, R., & Halonen, T. (2011). High-throughout analysis of testosterone in serum samples by on-line solidphase extraction liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med., 49(11): 1845–8. doi: 10.1515/cclm.2011.663.

[3] Vogeser, M., Rieger, C., Ostermann, H., & Spöhrer, U. (2009). A routine method for the quantification of the novel antimyotic drug posaconazole in plasma using liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med., 47(5): 579–84. doi: 10.1515/cclm.2009.129.

[4] Kirchhoff, F., Lorenzl, S., & Vogeser, M. (2010). An on-line solid phase extraction procedure for the routine quantification of urinary methylmalonic acid by liquid chromatography- tendem mass spectrometery. Clin Chem Lab Med., 48(11): 1647–50. doi: 10.1515/cclm.2010.310.

[5] Benton, S.C., Tetteh, G.K., Needham, S.J., Mücke, J., Sheppard, L., Alderson, S., et al. (2020). Evaluation of the 25-hydroxy vitamin D assay on a fully automated liquid chromatography mass spectrometery system, the thermo scientific cascadion Sm clinical analyzer with the cascadio 25- hydroxy vitamin D assay in a routine clinical laboratory. Clin Chem Lab Med., 58(6): 1010–7. doi: 10.1515/cclm-2019-0834.

[6] Skaggs, C.L., Ren, G.J., Elgierari, E.T.M., Sturmer, L.R., Shi, R.Z., Manicke, N.E., et al. (2020). Simultaneous quantitation of five trizole antifungal agents by paper spray-mass spectrometery. Clin Chem Lab Med., 58(5): 836–46. doi: 10.1515/cclm-2019-0895.

[7] Vogeser, M., & Spöhrer, U. (2006). Automated processing of whole blood samples for the determination of immunosuppressants by liquid chromatography tandem- mass spectrometery. Clin Chem Lab Med., 44(9): 1126–30. doi: 10.1515/CCLM.2006.199.

[8] Bremer, H.J. (n.d). Disturbances of amino acid metabolism: clinical chemistry and diagnosis; urban & Schwarzenberg. Baltimore, Page 198.

[9] Holmes, M.R. Ramkissoon K.R, & Giddings M.C. (2005). Proteomics and protein identification. Bioinformatics. 3rd Ed., Pages 445–72.

[10] Wulfkuhle, J.D., Liotta, L.A., & Petricoin, E.F. (2003). Proteomic applications for the early detection of cancer. Nat Rev Cancer, 3(4): 267–75. doi: 10.1038/nrc1043.

[11] Antoniewicz, M.R., Kelleher, J.K., & Stephanopoulos, G. (2011). Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry. Anal Chem., 83(8): 3211–6. doi: 10.1021/ac200012p.

[12] McClure, T.D., Schram, K.H., & Reimer, M.L.J. (1992). The mass spectrometry of Taxol. J Am Soc Mass Spectrom., 3(6): 672–9. doi: 10.1016/1044-0305(92)85009-9.

[13] Sarossy, Z., Plackett, D., & Egsgaard, H. (2021). Carbohydrate analysis of hemicelluloses by gas chromatography-mass spectrometery of acetylated methyl glycosides. Anal Bioanal Chem., 403(7): 1923–30.

[14] Berlin, K., Jain, R.K., Tetzlaff, C., Steinbeck, C., & Richert, C. (1997). Spectrometrically monitored selection experiments: quantitative laser desorption mass spectrometry of small chemical libraries. Chem Biol., 4(1): 63–77. doi: 10.1016/s1074-5521(97)90237-4.

[15] Wang, T., Zeng, L., Strader, T., Burton, L., & Kassel, D.B. (1998). A new ultra-high throughput method for characterizing combinatorial libraries incorporating a multiple probe autosampler coupled with flow injection mass spectrometry analysis. Rapid Commun Mass Spectrom., 12(16): 1123–9. doi: 10.1002/(SICI)1097-0231.

[16] Burlingame, A.L., Boyd, R.K., & Gaskell, S.J. (1998). Mass spectrometry. Anal Chem., 70(16): 647R–716R. doi: 10.1021/a1980023.

[17] Taguchi, V.Y., Nieckarz, R.J., Clement, R.E., Krolik, S., & Williams, R. (2010). Dioxin analysis by gas chromatography-Fourier transform ion cyclotron resonance mass spectrometry (GC-FTICR-MS). J Am Soc Mass Spectrom., 21(11): 1918–21. doi: 10.1016/j.jasms.2010.07.010.

[18] Tang, P. (2017). Determination of Posaconazole in Plasma/Serum by High-Performance Liquid Chromato- graphy with Fluorescence Detection. Separations, 4(2): 16. doi: https://doi.org/10.3390/separations4020016.
[19] Thomas, S.N., French, D., Jannetto, P.J., Rappold, B.A., & Clarke, W.A. (2022). Liquid chromatography–tandem mass spectrometry for clinical diagnostics. Nature Reviews Methods Primers, 2(1). doi: https://doi.org/10. 1038/s43586-022-00175-x.

[20] Bjerg, L.N., Halgreen, J.R., Hansen, S.H., Morris, H.A., & Jørgensen, N.R. (2019). An evaluation of total 25-hydroxyvitamin D assay standardization: Where are we today? The Journal of Steroid Biochemistry and Molecular Biology, 190: 224–233. doi: https://doi.org/10.1016/j.jsbmb.2019.03.015.

[21] Hörber, S., Peter, A., Lehmann, R., & Hoene, M. (2021). Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine. Clin Chem Lab Med., 59(5): 913-20. doi: 10.1515/cclm-2020-0848.

[22] Pan, L., Fan, X., Jia, A., Li, Y., Zhao, Y., Liu, Y., Wang, A., & Ma, Y. (2023). High-throughput identification and determination of antifungal triazoles in human plasma using UPLC-QDa. Journal of Chromatography B., 1226: 123774. doi: https://doi.org/10.1016/j.jchromb.2023.123774.

[23] Dolman, M.E.M., den Hartog, I.J.M., Molenaar, J.J., Schellens, J.H.M., Beijnen, J.H., & Sparidans, R.W. (2014). Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma. Journal of Pharmaceutical and Biomedical Analysis, 92: 144–148. doi: https://doi.org/10.1016/j.jpba.2014.01.011.

[24] Aliu, E., Kanungo, S., & Arnold, G.L. (2018). Amino acid disorders. Annals of Translational Medicine, AME Publishing Company, 6(24): 471–471. doi: https://doi.org/10.21037/atm.2018.12.12.

[25] Ryu, S.Y. (2014). Bioinformatics Tools to Identify and Quantify Proteins Using Mass Spectrometry Data. Advances in Protein Chemistry and Structural Biology, Pages 1–17, Elsevier. doi: https://doi.org/10.1016/b978-0- 12-800168-4.00001-9.

[26] Hunter, B., Hindocha, S., & Lee, R.W. (2022). The Role of Artificial Intelligence in Early Cancer Diagnosis. Cancers, 14(6): 1524. doi: https://doi.org/10.3390/cancers14061524.

[27] Harbeson, S.L., & Tung, R.D. (2011). Deuterium in Drug Discovery and Development. Annual Reports in Medicinal Chemistry, Pages 403–417, Elsevier. doi: https://doi.org/10.1016/b978-0-12-386009-5.00003-5.

[28] Huang, H., Sun, Y., & Liu, Q. (2023). The Quantification of Paclitaxel and Its Two Major Metabolites in Biological Samples by HPLC-MS/MS and Its Application in a Pharmacokinetic and Tumor Distribution Study in Xenograft Nude Mouse. Molecules, 28(3). doi: https://doi.org/10.3390/molecules28031027.

Source of Funding:

This study did not receive any grant from funding agencies in the public or not-for-profit sectors.

Competing Interests Statement:

The authors have declared no competing interests.

Consent for Publication:

The authors declare that they consented to the publication of this study.

Author’s Contribution:

All authors took part in data collection, literature review, analysis, and manuscript writing equally.