The greener and cost-effective synthesis of an oxovanadium complex of mebendazole is described. The synthesis involves the use of distilled water as a solvent and refluxing, providing environmentally friendly advantages, simple work-up procedures, and a short reaction time with excellent yield. Characterization included UV-Vis and FTIR spectroscopy. The UV-Vis spectra showed intra-ligand transitions at 242 and 269 nm and charge transfer bands at 310 and 380 nm, indicating the formation of oxovanadium complex of mebendazole. The FTIR spectra confirmed coordination via the nitrogen and oxygen atoms of the ligand, evidenced by shifts in C-H, C=C, and C-O stretching bands, the appearance of a new V=O band at 977.94 cm⁻¹, and an OV-N bending band at 497.65 cm⁻¹. The metal complex with the formula [VO(L)]SO₄ was deduced, where L is mebendazole.

Keywords: Oxovanadium, Mebendazole, Synthesis, Characterization, Spectroscopy, UV-Vis, FTIR, Physico-chemical, Ligand, Antibiotic, Green synthesis, Coordination complex.

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Source of Funding:

This study did not receive any grant from funding agencies in the public, commercial, or not–for–profit sectors.

Competing Interests Statement:

The authors declare no competing financial, professional, or personal interests.

Consent for publication:

The authors declare that they consented to the publication of this study.

Authors' contributions:

Both the authors made an equal contribution in the Conception and design of the work, Data collection, Drafting the article, and Critical revision of the article. Both the authors have read and approved the final copy of the manuscript.

Acknowledgments:

The authors thank Department of Chemistry, Federal University Otuoke for facilities and space, and International Foundation for science for the JASCO-V730 UV-Vis spectrophotometer used to record the UV-Vis spectra of the ligands and complexes.